Malat1 endothelial

Author: wnrg

August undefined, 2024

Web10 sep. 2024 · Background . Endothelial dysfunction commonly occurs in obese children and adolescents, leading to an increased risk of cardiovascular diseases. Exercise has significant protective effects against endothelial dysfunction through regulating some noncoding RNAs. This study aimed to investigate the relationship of long noncoding RNA … Web6 okt. 2024 · MALAT1 knockdown significantly improved viability and suppressed the apoptosis of LPS-stimulated HPAEpiC. Moreover, MALAT1 directly targeted miR-194-5p, ... in VILI yet. Methods: To screen the differential expression of lncRNAs and mRNAs in Human pulmonary microvascular endothelial cells (HPMECs) subjected to cyclic stretch, ...

LncRNA MALAT1 up-regulates VEGF-A and ANGPT2 to promote

WebMALAT1 is a highly conserved nuclear long non-coding RNA molecule. In this study, we examined the role of MALAT1 in chronic diabetic … WebMALAT1 modulates TGF-β1-induced EndMT of EPCs through regulation of TGFBR2 and SMAD3 via miR-145. Thus, the MALAT1-miR-145-TGFBR2/SMAD3 signaling pathway plays a key role in TGF-β1-induced EndMT. MALAT1 modulates TGF-β1-induced EndMT of … humans achieve more by cooperating

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Web13 apr. 2024 · 经国家自然科学基金委员会监督委员会五届十六次会议审议、国家自然科学基金委员会2024年第2次委务会议审定，决定依据《国家自然科学基金项目科研不端行为调查处理办法》（国科金发诚〔2024〕96号）第四十七条、第四十条、第四十六条，撤销张亚东国 … WebLncRNA MALAT1 Promotes STAT3-Mediated Endothelial Inflammation by Counteracting the Function of miR-590. The excessive production of inflammatory mediators by vascular endothelial cells (ECs) greatly contributes to the development of atherosclerosis. Web28 nov. 2024 · MALAT1 deficiency was previously shown to reduce endothelial cell proliferation, 6 and this might also have contributed to augmented atherosclerosis, particularly in the low-flow regions of the vascular tree, where endothelial cell proliferation is an important protective repair mechanism. 26 On the other hand, one may speculate that … human sacrifice in africa

Long noncoding RNA MALAT1 regulates endothelial cell function and ...

WebLncRNA MALAT1 facilitates BM-MSCs differentiation into endothelial cells via targeting miR-206/VEGFA axis. Bone marrow-derived mesenchymal stem cells (BM-MSCs) implantation shows a repair effect on erectile function in diabetes mellitus-induced … Web16 dec. 2024 · In summary, MALAT1 suppression protects the endothelium from oxLDL-induced inflammation and oxidative stress in endothelial cells by upregulation of miR-181b and downregulation of TOX. 1. Introduction Atherosclerosis (AS), induced by plaque formation inside the arteries, is a lethal condition responsible for heart attack and stroke [ … human ruffec 16700WebMetastasis-associatedlungadenocarcinomatranscript1 (MALAT1) is a widely investigated long noncoding RNA (lncRNA) and has been reported to be related with endo- thelial function [11–13]. hollow 2/4 zincromate

"Web19 dec. 2024 · Michalik KM, You X, Manavski Y, Doddaballapur A, Zornig M, Braun T, et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res. 2014;114:1389–97. " - Malat1 endothelial

Malat1 endothelial

LncRNA MALAT1 Suppression Protects Endothelium against oxLDL …

Web14 dec. 2024 · MALAT1 silencing significantly downregulated the expression of the miR-181b target gene TOX via reversing the effect of miR181b. Importantly, positive modulation of miR181b and inhibition of MALAT1 and TOX significantly attenuated … WebA previous study indicated that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) promotes neuronal death via targeting miR-30a in ischemic stroke. 49 It protects the cerebral microvasculature and parenchyma from cerebral ischemic insults by inhibiting endothelial cell death and inflammation and plays roles in the progression of ...

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Web18 jan. 2024 · Findings from our in vitro experiments demonstrated that MALAT 1 was predominantly localized to nuclear speckles in endothelial cells and MALAT 1 expression was significantly increased following incubation with high glucose in association with increased expression of inflammatory cytokines. Web25 apr. 2024 · Here, we first determined the expression level of MALAT1 in human retinal microvascular endothelial cells (HRECs) cultured in high glucose (HG) and subsequently analyzed the expressions of...

WebPrevious results suggested that Sirt6 mediated transcriptional suppression of MALAT1 is a key mechanism for EndMT in a model of ECs aging, 26 future research should focus on the role of Sirt6 and target ... Qin W, Zhang L, Li Z, et al. SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal ... WebMALAT1, originally identified in pulmonary adenocarcinoma, is among the most abundant lncRNA in the nervous system. It is described as heavily expressed in different types of neurons in mice (Bernard et al., 2010 ). MALAT1 is found in nuclear foci and appears to regulate synapse formation ( Bernard et al., 2010 ).

Webpaper showed that MALAT1 controls a phenotypic switch in endothelial cell and regulates its function and vessel growth [18]. It has also been demonstrated that MALAT1 plays a pathogenic role in endothelial cell dysfunction in diabetes mellitus [19]. However, whether MALAT1 is in-volved in regulating EPC function in T2DM remains un-known. WebMALAT1 is associated with vascular endothelial cell homeostasis , and reduced MALAT1 expression may impede vascular repair after SARS-CoV-2 infection. MT-CO1 (ENSG00000198804), as a second parameter, was downregulated in vascular endothelial cells after SARS-CoV-2 infection in this rule.

Web19 mrt. 2015 · MALAT1 (AKA NEAT2: noncoding nuclear-enriched abundant transcript 2, HCN, LINC000 47) is a large, infrequently spliced non-coding RNA, which is highly conserved. MALAT1 is expressed in the nucleus and was originally described to regulate …

WebMoreover, miR-126-5p inhibitor increased VCAM1, ICAM-1, MCP-1 and Nuclear P65 expressions, but reduced that of Cytoplasmic P65 in LPS-induced HRGECs and MGECs, and partially offset the effect of sh MALAT1 on the above protein expressions. Conclusions: MALAT1 silencing reduces LPS-induced glomerular endothelial cell damage by … human – s01 tamil dubbed series hdhttp://www.antpublisher.com/index.php/APT/article/download/222/276 hollow 20x10Web14 okt. 2024 · MALAT1 is one of the most abundant lncRNAs in platelets. However, the functional roles of MALAT1 in platelets are unexplored. What this study adds In this study, the function of MALAT1 in platelets was investigated in vitro and in vivo. hollow 2015Web6 jan. 2024 · Knocking down of MALAT1 and miR-181a-5p could both improve the outcome in ALI/ARDS rats. MALAT1 antagonism or miR-181a-5p could both be potential ... Manavski Y, Doddaballapur A, Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth ... hollow 20x60Web5 feb. 2024 · Long noncoding RNA MALAT1 promotes high glucose-induced inflammation and apoptosis of vascular endothelial cells by regulating miR-361-3p/SOCS3 axis. Kai Huang, Xuxia Yu, Yushan Yu, Lu Zhang, Y. Cen, Jinguo Chu Biology, Medicine International journal of clinical and experimental pathology 2024 TLDR hollow 25WebEndothelial-specific overexpression of MYC was sufficient to induce type H bone endothelial cells, ... In this study, the effect of the lncRNA … human sacrifice in religionWebExosomal MALAT1 derived from oxidized low-density lipoprotein-treated endothelial cells promotes M2 macrophage polarization. Oxidized low-density lipoprotein (oxLDL)-induced injury and apoptosis of endothelial cells are important initial events in numerous … human sacrifice in ancient china